Bridging Science to Life
JN Biosciences LLC
320 Logue Avenue
Mountain View, CA 94043
Multimeric IgG antibodies (MultYbodies™) against immune costimulatory molecues of the TNF receptor superfamily members (OX40, CD40, GITR, 4-1BB and others), which were generated using JN Biosciences' proprietary MultYmab™ antibody engineering technology, function as potent agonists of these receptors and strong inducers of immune responses.
The multimeric humanized anti-OX40 IgG antibody, HuOHX10-MultYbody™, which is a leading therapeutic candidate in this program, exhibited potent activities to stimulate immune responses of T cells. Its activity was enhanced in the presence of an anti-PD-1 antibody (click here for the data). HuOHX10-MultYbody™ is available for out-licensing.
The proprietary MultYmab™ technology has also been applied to generation of agonist antibodies against other constimulatory molecules such as CD40, GITR, 4-1BB, CD27 and HVEM. Characterization of these antibodies is in progress.
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JN Biosciences LLC
320 Logue Avenue
Mountain View, CA 94043