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JN Biosciences LLC
320 Logue Avenue
Mountain View, CA 94043
HuYON007 MultYbody™ is a humanized anti-death receptor 4 (DR4) IgG1 antibody which has been converted to an agonist using JN Biosciences' proprietary MultYmab™ antibody engineering technology. HuYON007 MultYbody™ potently induces apoptosis of DR4-expressing tumor cell lines such as Burkitt's lymphoma Ramos, multiple myeloma RPMI-8226, colon carcinoma COLO 205 and pancreatic carcinoma MIA PaCa-2. In a systemic xenograft model with each of Ramos and RPMI-8226 cells, HuYON007 was significantly more efficacious than non-engineered HuYON007 IgG1 for survival of the mice. HuYON007 MultYbody™ is being developed for treatment of cancer. For additional information of HuYON007 MultYbody™, a non-confidential brochure is available here.
HuGOH729S MultYbody™ is a humanized anti-death receptor 5 (DR5) IgG1 antibody which has been converted to an agonist using JN Biosciences' proprietary MultYmab™ antibody engineering technology. HuGOH729S MultYbody™ potently induces apoptosis of DR5-expressing tumor cell lines such as acute T cell leukemia Jurkat, colon carcinoma COLO 205 and ovarian carcinoma OVCAR-3. The therapeutic efficacy of HuGOH729S MultYbody™ is currently being examined.
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JN Biosciences LLC
320 Logue Avenue
Mountain View, CA 94043