JN Biosciences LLC

HuYON007 MultYbody™ is a humanized anti-death receptor 4 (DR4) IgG1 antibody which has been converted to an agonist using JN Biosciences' proprietary MultYmab™ antibody engineering technology.  HuYON007 MultYbody™ potently induces apoptosis of DR4-expressing tumor cell lines such as Burkitt's lymphoma Ramos, multiple myeloma RPMI-8226, colon carcinoma COLO 205 and pancreatic carcinoma MIA PaCa-2.  In a systemic xenograft model with each of Ramos and RPMI-8226 cells, HuYON007 was significantly more efficacious than non-engineered HuYON007 IgG1 for survival of the mice.  HuYON007 MultYbody™ is being developed for treatment of cancer.  For additional information of HuYON007 MultYbody™, a non-confidential brochure is available here.

HuGOH729S MultYbody™ is a humanized anti-death receptor 5 (DR5) IgG1 antibody which has been converted to an agonist using JN Biosciences' proprietary MultYmab™ antibody engineering technology.  HuGOH729S MultYbody™ potently induces apoptosis of DR5-expressing tumor cell lines such as acute T cell leukemia Jurkat, colon carcinoma COLO 205 and ovarian carcinoma OVCAR-3.  The therapeutic efficacy of HuGOH729S MultYbody™ is currently being examined.