JN Biosciences LLC

Bridging Science to Life

JN Biosciences LLC
320 Logue Avenue
Mountain View, CA 94043

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  • ManagementClick to open the Management menu
    • Naoya Tsurushita, Ph.D.
    • J Yun Tso, Ph.D.
  • Technology
  • PipelineClick to open the Pipeline menu
    • CD122
    • Death Receptors
    • Costimulatory Molecules
    • Checkpoint Molecules
    • Bispecific antibodies
  • Humanization
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Anti-CD122 Antibody

CD122 is an integral part of both the interleukin-2 (IL-2) and interleukin-15 (IL-15) receptors.  HuABC2 is a humanized anti-CD122 IgG antibody that has a unique function to suppress CD122/CD132-bearing NK and memory T cells, but not CD25/CD122/CD132-bearing Treg cells, which makes HuABC2 suitable for treatment of autoimmune disease and transplant.

In non-human primates, HuABC2 showed a good safety profile, suppressed renewal of CD8+ memory T cells and NK cells, and demonstrated ability to prolong survival of non-human primates receiving life-sustaining kidney allografts.  Notably, Treg cells were not suppressed by treatment with HuABC2 (click here for the publication of JN Biosciences' academic collaborators). 

ChMBC7, a surrogate of HuABC2, is a rat-mouse chimeric IgG antibody that binds to and blocks the function of mouse CD122.  Therapeutic activity of ChMBC7 was demonstrated in mouse disease models of skin allograft, type I diabetes and vitiligo by JN Biosciences' collaborators.  Other academic researchers also reported the therapeutic efficacy of an anti-CD122 antibody in the mouse models of celiac disease, type I diabetes and alopecia areata.

HuABC2 is expected to be efficacious for treatment of a variety of immune-mediated diseases in humans, including vitiligo, alopecia areata, type I diabetes, celiac disease, multiple sclerosis, Behcet's disease and organ transplant rejection, in which the involvement of pathogenic NK and CD8+ memory T cells are indicated in the onset and/or maintenance of diesease conditions.  A summary of HuABC2 is placed here.     

HuABC2 is available for out-licensing.  For inquiry, please contact us by email at info(at)jn-bio.com (convert (at) to @).

Copyright 2019 JN Biosciences. All rights reserved.

 

JN Biosciences LLC
320 Logue Avenue
Mountain View, CA 94043